Tumor Necrosis Factor-α Is Expressed in Donor Heart and Predicts Right Ventricular Failure After Human Heart Transplantation
作者： Emma J. Birks , Virginia J. Owen , Paul B. J. Burton , Anne E. Bishop , Nicholas R. Banner
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摘要: Background—Myocardial failure is an important problem after heart transplantation. Right ventricular (RV) most common, although its mechanisms remain poorly understood. Inflammatory cytokines play role in failure. We studied the expression of tumor necrosis factor (TNF)-α and other donor myocardium their relationship to subsequent development RV early Methods Results—Clinical details were obtained, function was assessed by transesophageal echocardiography 26 donors before retrieval. A biopsy obtained immediately transplantation, each recipient followed for Reverse transcriptase–polymerase chain reaction performed detect TNF-α, interleukin-2, interferon-γ, inducible nitric oxide synthase expression. Eight recipients (30.8%) developed Seven these 8 (87.5%) expressed but only 4 18 (22.2%) who ...
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