The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands
作者： Adam J. Pawson , Joanna L. Sharman , Helen E. Benson , Elena Faccenda , Stephen P.H. Alexander
DOI: 10.1093/NAR/GKT1143
关键词:
摘要: The International Union of Basic and Clinical Pharmacology/British Pharmacological Society (IUPHAR/BPS) Guide to PHARMACOLOGY (http://www.guidetopharmacology.org) is a new open access resource providing pharmacological, chemical, genetic, functional pathophysiological data on the targets approved experimental drugs. Created under auspices IUPHAR BPS, portal provides concise, peer-reviewed overviews key properties wide range established potential drug targets, with in-depth information for subset important targets. result curation integration from Database (IUPHAR-DB) published BPS 'Guide Receptors Channels' (GRAC) compendium. are derived global network expert contributors, extensively linked relevant databases, including ChEMBL, DrugBank, Ensembl, PubChem, UniProt PubMed. Each ∼6000 small molecule peptide ligands annotated manually curated 2D chemical structures or amino acid sequences, nomenclature database links. Future expansion will complete coverage all currently drugs future candidate alongside educational resources guide scientists students in pharmacological principles techniques.
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