Co-axial wet-spinning in 3D bioprinting: state of the art and future perspective of microfluidic integration.

摘要: Nowadays, 3D bioprinting technologies are rapidly emerging in the field of tissue engineering and regenerative medicine as effective tools enabling fabrication advanced constructs that can recapitulate vitro organ/tissue functions. Selecting best strategy for bioink deposition is often challenging time consuming process, properties-in first instance, rheological gelation-strongly influence suitable paradigms its deposition. In this short review, we critically discuss one available approaches used bioprinting-namely co-axial wet-spinning extrusion. Such a system, fact, demonstrated to be promising terms printing resolution, shape fidelity versatility when compared other methods. An overview performances technology cellularized hydrogel fibres discussed, highlighting main features. Furthermore, show how approach allows (i) decouple accuracy from behaviour-thus notably simplifying development new bioinks-and (ii) build heterogeneous multi-materials and/or multicellular better mimic native tissues combined with microfluidic systems. Finally, ongoing challenges future perspectives ultimate functional research studies highlighted.