Soluble intercellular adhesion molecule-1, E-selectin, vascular cell adhesion molecule-1 and von Willebrand factor in stroke

摘要: We investigated the role of endothelial cell and leukocyte adhesion in pathophysiology acute stroke. The immunocytochemical expression molecules brain tissue from six patients who died following ischaemic stroke showed weak intercellular molecule-1 (ICAM-1), but intense vascular (VCAM-1) by astrocytes cells infarcted, not non-infarcted areas. also measured soluble E-selectin, ICAM-1, VCAM-1 von Willebrand factor (all enzyme-linked immunosorbent assay) 21 after an (ictus < 12 h), again 3 months later. Blood levels were compared with 82 healthy controls 22 subjects carotid atherosclerosis. Compared controls, both patient groups had raised (P 0.02) level was only 0.02). Levels still high at follow-up. suggest that there might be changes molecule release chronic stages stroke, where blood are related to findings on infarcted brain. These may perhaps part complex pathophysiological responses infarction repair