Retrovirus-induced immunodeficiency in mice exacerbates gastrointestinal candidiasis

摘要: Dysfunction of neutrophils in patients infected with human immunodeficiency virus is at least partly responsible for secondary microbial diseases these individuals, including invasive gastrointestinal (GI) candidiasis. Immunoregulatory disturbances associated the development AIDS virus-infected exacerbates Candida albicans infection upper GI tract and frequently leads to oropharyngeal esophageal In this article, we present first report a murine model candidiasis an AIDS-related syndrome that results from C57BL/6 mice previously described retrovirus complex (LP-BM5). Mice inbred strain were C. by oral-intragastric inoculation as infants intraperitoneal route 30 days later. Control same above subsequently avirulent, ecotropic helper (MBI-5). Animals killed 90 after retroviral challenge. Total differential blood cell counts, CD4+ T-cell counts spleen, histopathology gastric mucosa experimental control animals determined. The virulent LP-BM5-infected developed showed eruptive suppurative lesions, mainly regions cardial-atrium fold stomach. Well-defined abscesses entrapped hyphae observed region mice. A significant increase number CFU homogenized plated segments was recognized versus animals. reported here permits examination nature interaction both immunocompetent host under conditions which yeast exists predominantly commensal organism immunosuppressed during progressive stages induced infection.