Accumulation of p27KIP1 is associated with BMP2-induced growth arrest and neuronal differentiation of human neuroblastoma-derived cell lines
作者： Yohko Nakamura , Toshinori Ozaki , Haruhiko Koseki , Akira Nakagawara , Shigeru Sakiyama
DOI: 10.1016/S0006-291X(03)01138-0
关键词:
摘要: Bone morphogenetic proteins (BMPs) play an essential role in cell fate determination. In this study, we found that BMP2 treatment resulted growth arrest and differentiation human neuroblastoma-derived lines, SH-SY5Y RTBM1. Within 30 min of exposure, phosphorylation Smad1/5 was observed these lines. RTBM1 cells, BMP2-induced accompanied by a significant decrease the expression level DAN, antagonist BMP frog embryos. Immunoblot analysis revealed caused down-regulation p53 family members hence cyclin-dependent kinase inhibitor p21WAF1. We accumulation p27KIP1 response to BMP2, whereas Skp2, which is required for ubiquitin-dependent degradation, decreased during process. Our results suggest contributes BMP-induced neuronal neuroblastoma, might provide new therapeutic strategy.
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