Increase in CCR5 Δ32/Δ32 genotype in multiple sclerosis

摘要: Chemokines and their receptors participate in the development of multiple sclerosis (MS) by guiding immune cells into brain tissue. A CCR5 Delta32 deletion mutation abolishes functional on cell surface may reduce entry lesion sites. To analyse significance this MS, we compared frequencies genotype peripheral blood mononuclear from 89 MS patients 119 healthy controls. The was further with RNA protein expression 48 In all patients, Delta32/32 found 6.7% frequency, whereas it present only 0.8% controls (6/89 vs 1/119, P = 0.01). Specifically, Delta32/Delta32 increased (11.5%, 0.05) among primary progressive 4.8% other subtypes amount CD4(+) analysed (nine 18 secondary 21 relapsing-remitting MS) 13 decreased genotype, being 8.9% wt/wt, 7.7% wt/Delta32 4.3% Delta32/Delta32. these significantly as that wt/wt individuals (P 0.004). number our suggests could contribute a general risk factor for MS. However, neither levels or correlated subtype, neurological disability expressed expanded status scale, disease progression index. Our results suggest lack does not protect but rather predispose to chronic course disease. This would imply view redundancy chemokine system, ligands must be assumed function through closely related receptors.