MiR-132 promotes the proliferation, invasion and migration of human pancreatic carcinoma by inhibition of the tumor suppressor gene PTEN.
作者： Hui Zhang , Aixiang Liu , Xielin Feng , Lang Tian , Wentao Bo
DOI: 10.1016/J.PBIOMOLBIO.2017.09.019
关键词:
摘要: MicroRNA (miRNAs) emerges as key oncogene or tumor suppressor in a variety of cancers including pancreatic carcinoma. In this study, we detected the role miR-132 development and progression cancer underlying mechanism. First, expression carcinoma adjacent non-cancerous tissues were by qRT-PCR. Then, biological function cells was investigated. Our results identified that generally upregulated carcinoma, phosphatase tensin homolog (PTEN) downregulated. PTEN associated with advanced size, lymph node metastasis Tumor-Nodes-Metastases (TNM) stage Downregulation inhibited proliferation, migration invasion cells. contrast, overexpression promoted The luciferase reporter system demonstrated is direct target miR-132. Overexpression abrogated induction on Taken together, promotes human inhibition PTEN, could be might candidate prognostic biomarker promising for new treatment cancer.
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