Adjuvant treatment for endometrial cancer: literature review and recommendations by the Comité de l'évolution des pratiques en oncologie (CEPO).

摘要: Abstract Objective Despite the very good prognosis of endometrial cancer, a number patients with localized disease relapse following surgery. Therefore, various adjuvant therapeutic approaches have been studied. The objective this review is to evaluate efficacy and safety neoadjuvant therapies in resectable cancer develop evidence-based recommendations. Methods A scientific literature published between January 1990 June 2012 was performed. search limited phase III clinical trials meta-analyses evaluating or carcinoma carcinosarcoma. total 23 studies five were identified. Results selected showed that low risk recurrence, post-surgical observation safe recommended most cases. There are several modalities available for treatment cancers higher including vaginal brachytherapy, external beam radiotherapy, chemotherapy, combination these. Conclusions Considering evidence date, CEPO recommends following: 1)post-surgical recurrence risk; 2)adjuvant brachytherapy an intermediate 3)adjuvant pelvic radiotherapy without high addition chemotherapy may be considered as option (excellent functional status, no significant co-morbidities, poor prognostic factors); 4)adjuvant para-aortic irradiation advanced disease; 5)hormonal therapy not setting.