Protein-Protein Interactions: Structures and Druggability

作者: David B. Ascher , Harry C. Jubb , Douglas E. V. Pires , Takashi Ochi , Alicia Higueruelo

DOI: 10.1007/978-94-017-9719-1_12

关键词:

摘要: While protein-protein interfaces have promised a range of benefits over conventional sites in drug discovery, they present unique challenges. Here we describe recent developments that facilitate many aspects the discovery process – including characterization and classification interfaces, identifying druggable strategies for inhibitor development.

参考文章(174)
S.M. Zurawski, F. Vega, E.L. Doyle, B. Huyghe, K. Flaherty, D.B. McKay, G. Zurawski, Definition and spatial location of mouse interleukin-2 residues that interact with its heterotrimeric receptor The EMBO Journal. ,vol. 12, pp. 5113- 5119 ,(1993) , 10.1002/J.1460-2075.1993.TB06206.X
S.A. Forbes, G. Bhamra, S. Bamford, E. Dawson, C. Kok, J. Clements, A. Menzies, J.W. Teague, P.A. Futreal, M.R. Stratton, The Catalogue of Somatic Mutations in Cancer (COSMIC). Current protocols in human genetics. ,vol. 57, ,(2008) , 10.1002/0471142905.HG1011S57
Eugene Valkov, Tim Sharpe, May Marsh, Sandra Greive, Marko Hyvönen, Targeting protein-protein interactions and fragment-based drug discovery. Topics in Current Chemistry. ,vol. 317, pp. 145- 179 ,(2011) , 10.1007/128_2011_265
Pawel Traczewski, Lidia Rudnicka, Treatment of systemic lupus erythematosus with epratuzumab. British Journal of Clinical Pharmacology. ,vol. 71, pp. 175- 182 ,(2011) , 10.1111/J.1365-2125.2010.03767.X
James K. Kranz, Celine Schalk-Hihi, Protein thermal shifts to identify low molecular weight fragments. Methods in Enzymology. ,vol. 493, pp. 277- 298 ,(2011) , 10.1016/B978-0-12-381274-2.00011-X
Bancinyane L. Sibanda, Susan E. Critchlow, Jake Begun, Xue Y. Pei, Stephen P. Jackson, Tom L. Blundell, Luca Pellegrini, Crystal structure of an Xrcc4–DNA ligase IV complex Nature Structural & Molecular Biology. ,vol. 8, pp. 1015- 1019 ,(2001) , 10.1038/NSB725
Ermanno Gherardi, Dimitri Y. Chirgadze, Jonathan P. Hepple, Hongjun Zhou, R. Andrew Byrd, Tom L. Blundell, Crystal structure of the NK1 fragment of HGF/SF suggests a novel mode for growth factor dimerization and receptor binding. Nature Structural & Molecular Biology. ,vol. 6, pp. 72- 79 ,(1999) , 10.1038/4947
Iva Navratilova, Andrew L. Hopkins, Fragment screening by surface plasmon resonance. ACS Medicinal Chemistry Letters. ,vol. 1, pp. 44- 48 ,(2010) , 10.1021/ML900002K
Alicia P Higueruelo, Harry Jubb, Tom L Blundell, Protein-protein interactions as druggable targets: recent technological advances. Current Opinion in Pharmacology. ,vol. 13, pp. 791- 796 ,(2013) , 10.1016/J.COPH.2013.05.009
Jasminka Boskovic, Angel Rivera-Calzada, Joseph D Maman, Pablo Chacón, Keith R Willison, Laurence H Pearl, Oscar Llorca, Visualization of DNA-induced conformational changes in the DNA repair kinase DNA-PKcs The EMBO Journal. ,vol. 22, pp. 5875- 5882 ,(2003) , 10.1093/EMBOJ/CDG555