Temporal demographic and epidemiologic variation in histologic subtypes of lung cancer: a literature review

摘要: Abstract This review describes the distribution of lung cancer between 4 major WHO histological sub-types and factors which may influence this. The effects intra- inter-observer variability on classification adenocarcinoma are discussed in relation to studies have claimed show an increase proportion this sub-type recent years. Variation introduced by use different sources pathological material difficulties interpretation large cell carcinoma taken as further examples possible error. Important differences age- sex-specific incidence individual sub-types, might point causative other than smoking described temporal changes geographical ethnic differences. types lifelong non-smokers is a model for investigation occurring result causes cigarette smoking. Finally, recommendations future made.