Clusterin mRNA and protein in Alzheimer's disease
作者： Shabnam Baig , Laura E. Palmer , Michael J. Owen , Julie Williams , Patrick G. Kehoe
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摘要: Clusterin, a multifunctional lipoprotein is expressed in number of tissues but expression particularly high the brain, where it binds to amyloid-β (Aβ), possibly facilitating Aβ transport into bloodstream. Its concentration peripheral blood was identified as potential biomarker for Alzheimer's disease (AD) and predicted retention (11)C-Pittsburgh Compound B temporal lobe. Single-nucleotide polymorphisms clusterin gene, CLU, are associated with risk developing AD. We measured mRNA levels control AD brains investigated relationship protein soluble, insoluble, plaque-associated Aβ. Clusterin were unchanged when normalized GAPDH modestly increased frontal cortex relation NSE MAP-2. Levels MAP-2 reduced cortex. did not correlate amount present. In cortex, higher APOE e4-negative no effect detected or thalamus. Overall unaltered neocortex does reflect content. The increase noted may passage this chaperone across blood-brain barrier further work needed determine how CLU variants influence development
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