Regulation of lipid metabolism by a lipid-carrying protein.
作者： MARY E. DEMPSEY
DOI: 10.1016/B978-0-12-152824-9.50014-9
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摘要: Publisher Summary This chapter discusses regulation of lipid metabolism by a lipid-carrying protein. It provides an overview some the recent work on protein originally called squalene and sterol carrier (SCP). SCP was discovered during attempts to purify rat liver membrane-bound enzymes catalyzing late steps in cholesterol biosynthesis. is known participate many aspects its regulation. absolute requirement for activation synthesis from lanosterol. has high affinity long-chain fatty acids considered be intracellular acid transport protein, like albumin, plasma acids. The also outlines purification structural characterization human SCP; development use antibody both abundance ubiquitous occurrence subcellular distribution; factors regulating level SCP, role adrenal steroidogenesis, malignant tissue.
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