The cellular fatty acid binding proteins: aspects of structure, regulation, and function.
作者： Nathan M. Bass
DOI: 10.1016/S0074-7696(08)61733-7
关键词: Biology 、 Function (biology) 、 Biochemistry 、 Binding protein 、 Ligand (biochemistry) 、 Cytosol 、 Intracellular 、 Coenzyme A 、 Energy source 、 Fatty acid-binding protein
摘要: Publisher Summary This chapter provides a comprehensive overview of the current state knowledge research with particular emphasis on evolving concepts fatty acid binding proteins (FABP) structure, regulation, and function. Long-chain acids provide main energy source most mammalian tissues also comprise essential components structural lipids cell membranes. The purification specific responsible for low-molecular-weight fatty-acid protein activity in different leads to characterization three structurally distinct FABP similar size, each product separate gene. cytosolic are generally named according their greatest abundance, liver FABP, intestinal heart muscle FABP. A role 40-kDa LPM-FABP as membrane carrier transport long chain into cells possibly other well is available. 14- 15-kDa FABPs may function intracellular acceptors carriers long-chain coenzyme (CoA) esters, maintaining ability tissues, particularly liver, intestine, heart, skeletal utilize over wide acutely varying ranges flux.
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