Cigarette smoking is an independent risk factor for type 2 diabetes: a four-year community-based prospective study.

摘要: Summary Objectives  We investigated the association between smoking and its additive effects with insulin resistance β-cell function on incidence of type 2 diabetes in a prospective population-based cohort study. Design method  A total 10 038 subjects were recruited from rural urban areas. All underwent 75 g oral glucose tolerance tests full biochemical assessments at baseline during 4-year follow-up period. The final analysis was limited to 4041 men due low rates women. Results  ex- heavy current smokers had highest 12·5% 11·1% respectively, compared never-smokers (7·9%) 4 years. After multivariate adjustment by Cox-proportional hazard model, reveal relative risk 1·60 (95% CI: 1·07–2·39), 2·06 (1·35–3·16, for <20 cigarettes/day) 2·41 (1·48–3·93, ≥20 respectively never smokers. new onset those homeostasis model assessment beta cell (HOMA-β) high (HOMA-IR) group both smokers. Conclusions  Smoking is an independent factor mellitus showed synergistic interaction status secretion developing diabetes. Given growing burden world, cessation should be considered as one key factors prevention treatment programmes.