Effect of imipramine and nortriptyline on left ventricular function and blood pressure in patients treated for arrhythmias

作者: Elsa-Grace V. Giardina , Lynne L. Johnson , Joseph Vita , J.Thomas Bigger , Rachel F. Brem

DOI: 10.1016/0002-8703(85)90240-6

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摘要: Abstract The effect of imipramine or nortriptyline on left ventricular function and orthostatic blood pressure was evaluated in 20 nondepressed cardiac patients treated for premature depolarizations (VPDs). Drug administered by mouth dose ranging used, 1 mg/kg/day (imipramine) 0.5 (nortriptyline), increased after four doses six (nortriptyline) until >80% suppression VPDs adverse effects occurred a maximum 5 3.5 given. Fourteen (70%) had VPD suppression, five p 30 mm Hg. There not significant relationship between dose, drug concentration, functional class change systolic but there age (

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