Single-dose daily administration of cyclosporin A for relapsing nephrotic syndrome.

摘要: Cyclosporin A (CsA) has been reported to be effective as a steroid-sparing agent in frequently relapsing nephrotic syndrome (FRNS). However, low efficacy sometimes observed selected patients with ste- roid-dependent FRNS. We speculated that peak level of CsA the blood might cause, and con- ducted prospective pilot study on such steroid-depen- dent FRNS examine whether single-dose daily administration would yield sufficient level, therefore satisfactory effect. Five children steroid-dependent FRNS, aged 7- 16 years, were enrolled study. All had treated prednisolone combined twice (T), which was subsequently replaced protocol (S), because poor roid-sparing Although mean dosage S significantly lower than T (S 2.4€1.1 mg/kg per day vs. 3.6€0.8 day, P<0.05), tended higher 764€122 ng/ml 358€250 ng/ml, P=0.1797) without trough elevation. As result, min- imum dose required for maintenance clinical remission 0.4€0.2 alternate days 0.6€0.4 days, P=0.0656). No evidence nephrotoxicity repeat renal biopsy performed 9 months after commencement one patient. These observations, although small number preliminary, suggest an attractive whom by conventional is associated