Benefits of cyclosporine absorption profiling in nephrotic syndrome: preprandial once-daily administration of cyclosporine microemulsion improves slow absorption and can standardize the absorption profile.

摘要: SUMMARY: Aim:  Cyclosporine is known to improve proteinuria in nephrotic syndrome (NS), but also associated with drug-related renal impairment. In this case series, therapeutic drug monitoring using the absorption profile was applied adults NS investigate efficacy and safety of once-daily administration cyclosporine microemulsion (CSAME). Methods:  Twenty patients received CSAME starting at 100–175 mg/day (1.4–3.1 mg/kg per day) once daily after breakfast. The area under concentration–time curve up 4 h (AUC0−4 h) determined each patient within 1 week start treatment. Thereafter, dose adjusted according profile. Results:  After 6 months, treatment improved test values compared those prior treatment, severe state eliminated all patients. No changes serum creatinine or blood urea nitrogen levels were observed. so that AUC0−4 h peak level fell range target values, resulting a significant decrease mean (P = 0.0001). Time variable among patients, when administered before breakfast, good achieved patients. Conclusion:  By NS, used achieve both reduction total exposure drug. Preprandial provided more stable cyclosporine. authors hope method will become standard procedure during these