SOX2 immunity and tissue resident memory in children and young adults with glioma

摘要: Therapies targeting immune checkpoints are effective in tumors with a high mutation burden that express multiple neo-antigens. However, glial including those seen children carry fewer mutations and there is an unmet need to identify new antigenic targets of anti-tumor immunity. SOX2 embryonal stem cell antigen implicated the biology glioma initiating cells. Expression by pediatric capacity system these patients recognize has not been previously studied. We examined expression on archived paraffin-embedded tissue from tumors. The presence T-cell immunity was both blood tumor-infiltrating T-cells young adults glioma. nature cells analyzed 37-marker panel using single-cell mass cytometry. expressed tumor but surrounding normal gliomas all grades. against this can be detected patients. Glial enriched for CD8/CD4 resident memory (TRM; CD45RO+, CD69+, CCR7-) phenotype, which co-express inhibitory PD-1, PD-L1 TIGIT. Tumors also contain natural killer reduced lytic granzyme. Our data demonstrate immunogenicity SOX2, specifically overexpressed Harnessing will likely require combined checkpoints.