Comparative pharmacokinetics and bioavailability study of percutaneous absorption of diclofenac from two topical formulations containing drug as a solution gel or as an emulsion gel.

摘要: In a 3-way cross-over study on 12 healthy adult volunteers, the percutaneous absorption of diclofenac (CAS 15307-79-6) was studied for two topical formulations containing 1% diclofenac. The relative bioavailability from test formulation (a solution gel) in terms Cmax and AUC, calculated amount drug reaching systemic circulation, found to be twice after application reference product (an emulsion gel). maximum concentration drug, both blood cutaneous less than 10% that obtained parenteral administration, which indirectly is indicative adverse effects normally related high concentrations, such as reached oral are unlikely experienced.