Immobilization of an anti-thrombogenic substance with a photo-reactive azide and a photo-crosslinking material

摘要: An anti-thrombogenic substance is immobilized on a base of medical device to impart properties the device. The method comprises steps applying photo-reactive azide derivative macromolecular material form bonding layer, coating layer with composed water-soluble photo-crosslinking containing substance, and irradiating ultraviolet light formed thereon develop inter-molecular covalent in layer. thus fixed onto base. Concurrently, which crosslinked. can be poly-m-azidostyrene, copolymers, poly-m-aziodstyrene styrene copolymers poly-m-azidostyrene methyl methacrylate. copolymer photo-dimeric monomer or monomer.