The toxicity of orally administered deoxynivalenol (vomitoxin) in rats and mice

摘要: Abstract Two studies were conducted with weanling male rodents in an attempt to ascertain more precisely the toxic effects of deoxynivalenol (DON). In a feeding study approximately 18-wk duration, groups 90 Swiss-Webster derived mice and 50 Sprague-Dawley rats fed commercial chow (118 ppb DON), 80 either ‘uncontaminated’ diet (53 DON) or contaminated (6250 both based on wheat. A 5-wk gavage was also performed, which 24 litters 5 Swiss-Webster-derived divided among following groups: untreated control group, solvent three treated receiving 0.75, 2.5 7.5 mg DON/kg body weight. While there interim kills study, most animals given mg/kg died during test period. Effects weight haematological parameters indicate that DON elicited some degree toxicity at all levels tested. The histopathological findings from suggest had immune system as well being gastro-intestinal irritant.