A 10-year experience of total pelvic exenteration for primary advanced and locally recurrent rectal cancer based on a prospective database.

摘要: Aim  The study was conducted in a dedicated centre treating the majority of Danish patients with intended curative total pelvic exenteration for primary advanced (PARC) or locally recurrent (LRRC) rectal cancer. We compared PARC and LRRC analysed postoperative morbidity mortality, long-term outcome. Method  There were 90 consecutive (PARC/LRRC 50/40) treated between January 2001 October 2010, recorded on prospectively maintained database. Results  median age 63 (32–75) years gender ratio 7 women to 83 men. All American Society Anesthesiologists level I II. Sacral resection performed five 15 (P = 0.002). R0 achieved 33 (66%) (38%) LRRC, R1 17 (34%) 20 (50%) R2 (13%) LRRC. more frequent (P = 0.007). Forty-four (49%) had no complications. Fifty-five major complications registered. Two (2.2%) died within 30 days, in-hospital mortality 5.6%. follow-up 12 (0.4–91) months. 5-year survival 46% 17% (P = 0.16). Conclusion  Pelvic is associated considerable but low an experienced centre. can improve survival, especially PARC. However, also justified