Preclinical cardiac dysfunction in transfusion-dependent children and young adults detected with low-dose dobutamine stress echocardiography
作者： William A. Suarez , Scott A. Snyder , Brian B. Berman , Gary M. Brittenham , Chandrakant R. Patel
DOI: 10.1016/S0894-7317(98)70136-1
关键词:
摘要: Abstract Transfusion-dependent (TD) patients develop cardiac iron overload that will eventually lead to pump failure. Low-dose dobutamine stress echocardiography may complement resting and identify preclinical myocardial dysfunction caused by early hemosiderosis. Twenty-six iron-overloaded TD had with 5 μg/kg per minute of dobutamine. Indexed left ventricular (LV) mass, LV dimensions, meridional wall stress, index were significantly increased. similar shortening fraction M-mode (40.5% ± 5.6% vs 39.4% 4.5%) but a lower mean ejection (53.3% 3.9% 46.8% 6.9%, P
sci-hub.se 参考文章(51)
MA Livrea, L Tesoriere, AM Pintaudi, A Calabrese, A Maggio, HJ Freisleben, D D'Arpa, R D'Anna, A Bongiorno, Oxidative stress and antioxidant status in beta-thalassemia major: iron overload and depletion of lipid-soluble antioxidants. Blood. ,vol. 88, pp. 3608- 3614 ,(1996) , 10.1182/BLOOD.V88.9.3608.BLOODJOURNAL8893608
C C Silliman, D J Dixon, V M Peterson, P A Lane, K M Hambidge, D L Mellman, Iron chelation by deferoxamine in sickle cell patients with severe transfusion-induced hemosiderosis: a randomized, double-blind study of the dose-response relationship. Journal of Laboratory and Clinical Medicine. ,vol. 122, pp. 48- 54 ,(1993)
Edward J. Lesnefsky, Tissue Iron Overload and Mechanisms of Iron-Catalyzed Oxidative Injury Free Radicals in Diagnostic Medicine. ,vol. 366, pp. 129- 146 ,(1994) , 10.1007/978-1-4615-1833-4_10
Gabriela Link, Arie Pinson, Chaim Hershko, Identification of Thiolic Sarcolemmal Proteins as a Primary Target of Iron Toxicity in Cultured Heart Cells Advances in Experimental Medicine and Biology. ,vol. 356, pp. 267- 276 ,(1994) , 10.1007/978-1-4615-2554-7_28
G Link, A Pinson, C Hershko, Ability of the Orally Effective Iron Chelators Dimethyl- and Diethyl- Hydroxypyrid-4-One and of Deferoxamine to Restore Sarcolemmal Thiolic Enzyme Activity in Iron-Loaded Heart Cells Blood. ,vol. 83, pp. 2692- 2697 ,(1994) , 10.1182/BLOOD.V83.9.2692.2692
J. Candell-Riera, L. Lu, L. Serés, J.B. González, J. Batlle, G. Permanyer-Miralda, H. García-del-Castillo, J. Soler-Soler, Cardiac hemochromatosis: beneficial effects of iron removal therapy. An echocardiographic study. American Journal of Cardiology. ,vol. 52, pp. 824- 829 ,(1983) , 10.1016/0002-9149(83)90422-8
G. CECCHETTI, A. BINDA, A. PIPERNO, F. NADOR, S. FARGION, G. FIORELLI, Cardiac alterations in 36 consecutive patients with idiopathic haemochromatosis: polygraphic and echocardiographic evaluation European Heart Journal. ,vol. 12, pp. 224- 230 ,(1991) , 10.1093/OXFORDJOURNALS.EURHEARTJ.A059873
William D. Spotnitz, Stanton P. Nolan, Donald L. Kaiser, M.Susan Dalton, Joseph W. Baker, James R. Shipe, Thomas L. Matthew, The reversal of amiodarone-induced perioperative reduction in cardiac systolic reserve in dogs Journal of the American College of Cardiology. ,vol. 12, pp. 757- 764 ,(1988) , 10.1016/0735-1097(88)90318-X
EGIDIO MARIOTTI, ALBERTO AGOSTINI, EMANUELE ANGELUCCI, GUIDO LUCARELLI, ERNESTO SGARBI, EUGENIC PICANO, Reduced Left Ventricular Contractile Reserve Identified by Low Dose Dobutamine Echocardiography as an Early Marker of Cardiac Involvement in Asymptomatic Patients with Thalassemia Major Echocardiography-a Journal of Cardiovascular Ultrasound and Allied Techniques. ,vol. 13, pp. 463- 472 ,(1996) , 10.1111/J.1540-8175.1996.TB00922.X
ANTHONY P. FREEMAN, ROBERT W. GILES, VASILI A. BERDOUKAS, PENELOPE A. TALLEY, I. PROVAN C. MURRAY, Sustained normalization of cardiac function by chelation therapy in thalassaemia major. Clinical and Laboratory Haematology. ,vol. 11, pp. 299- 307 ,(1989) , 10.1111/J.1365-2257.1989.TB00227.X