The effects of morphine and nalorphine-like drugs in the nondependent, morphine-dependent and cyclazocine-dependent chronic spinal dog.

摘要: A series of morphine-like and nalorphine-like drugs were studied in the nondependent, morphine-dependent cyclazocine-dependent chronic spinal dog. In nondependent dog, three profiles activity found which could be utilized to distinguish between morphine, WIN 35, 197-2 cyclazocine. Propiram, a prototypic partial agonist morphine type, produced effects dogs both precipitated suppressed abstinence as was needed precipitate dogs. 197-2, strong guinea-pig ileum has been shown resistant antagonism by naloxone, neither nor but cyclazocine abstinence. it depressed flexor reflex not skin twitch reflex. Cyclazocine altered much like tachycardia, tachypnea, mydriasis canine delirum. The withdrawal syndromes qualitatively different. Twenty times naltrexone Nalorphine appeared nalorphine-type. Morphine syndrome. Cross-tolerance observed ketocyclazocine-dependent These data are consistent with hypothesis that there agonists mu kappa types, further, physical dependence on is mediated through different receptors. appears pure type. antagonist mixed sigma agonist.