The longer-term cognitive effects of adjunctive antiepileptic treatment with lacosamide in comparison with lamotrigine and topiramate in a naturalistic outpatient setting

摘要: In this retrospective controlled study, the impact of adjunctive lacosamide (LCM) on cognition in patients with epilepsy was evaluated and compared that topiramate (TPM) lamotrigine (LTG) a naturalistic outpatient setting. Cognition investigated by means objective assessment executive functions (EpiTrack®) verbal memory subjective ratings self-perceived side effects (cognition, mood, vegetative). Quality life assessed using QOLIE-10 questionnaire. Patients underwent at baseline after median follow-up interval 32 weeks. Forty-four were treated LCM, 11 LTG, 15 TPM. Treatment arms differed regard to age onset (LTG>TPM) seizure control from follow-up, which best whose seizures LTG (55% vs. 16% LCM 13% TPM). Groups did not differ type epilepsy, daily drug load or change, nor frequency. Repeated measures statistics controlling for outcome showed deteriorated TPM (F=7.5, p=0.001). On an individual level (reliable change indices), 53% losses domain (LCM 14%, 27%) none improvement 23%, 27%; χ(2)=11.8, p=0.019). No differences memory, quality life, mood noted among three treatment arms. Subjective cognitive complaints increased 5 9 1/9, 0/9; χ(2)=11.9, p=0.025). The findings study demonstrate first time effect profile is comparable superior This indicated both measures. Given setting nature prospective, randomized trial larger sample sizes required confirm these findings.