Degradation of microRNAs by a family of exoribonucleases in Arabidopsis.
作者： Vanitharani Ramachandran , Xuemei Chen
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摘要: microRNAs (miRNAs) play crucial roles in numerous developmental and metabolic processes plants animals. The steady-state levels of miRNAs need to be properly controlled ensure normal development. Whereas the framework miRNA biogenesis is established, factors involved degradation remain unknown. Here, we show that a family exoribonucleases encoded by SMALL RNA DEGRADING NUCLEASE (SDN) genes degrades mature Arabidopsis. SDN1 acts specifically on single-stranded vitro sensitive 2'-O-methyl modification 3' terminal ribose miRNAs. Simultaneous knockdown three SDN vivo results elevated pleiotropic defects. Therefore, have uncovered enzymes degrade demonstrated turnover for plant
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