Programmed Cell Death in T Cell Development

作者: Qian Nancy , Troy A.

DOI: 10.5772/48607

关键词:

摘要: The mammalian immune system is a complex network of many cell types and proteins that collectively coordinate protective response against foreign entities. can be divided into two broad categories: innate adaptive immunity. Adaptive immunity, which primarily mediated by T B lymphocytes, first arose in jawed vertebrates has several distinct features from the more ancient (Pancer Cooper 2006). While immunity characterized non-specific recognition conserved molecular patterns leading to rapid effector response, delayed required expansion lymphocytes bearing receptors specific for particular antigen. After primary small fraction activated remain as memory cells, respond subsequent encounters with same antigen robust manner.

参考文章(174)
Claude Saint-Ruf, Maddalena Panigada, Orly Azogui, Pascale Debey, Harald von Boehmer, Fabio Grassi, Different initiation of pre-TCR and γδTCR signalling Nature. ,vol. 406, pp. 524- 527 ,(2000) , 10.1038/35020093
A. Y. W. Suen, T. A. Baldwin, Proapoptotic protein Bim is differentially required during thymic clonal deletion to ubiquitous versus tissue-restricted antigens Proceedings of the National Academy of Sciences of the United States of America. ,vol. 109, pp. 893- 898 ,(2012) , 10.1073/PNAS.1114834109
Charles L. Sentman, John R. Shutter, David Hockenbery, Osami Kanagawa, Stanley J. Korsmeyer, bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes Cell. ,vol. 67, pp. 879- 888 ,(1991) , 10.1016/0092-8674(91)90361-2
Jared?F. Purton, Yifan Zhan, Douglas?R. Liddicoat, Charles?L. Hardy, Andrew M. Lew, Timothy?J. Cole, Dale?I. Godfrey, Glucocorticoid receptor deficient thymic and peripheral T cells develop normally in adult mice. European Journal of Immunology. ,vol. 32, pp. 3546- 3555 ,(2002) , 10.1002/1521-4141(200212)32:12<3546::AID-IMMU3546>3.0.CO;2-S
M S Vacchio, V Papadopoulos, J D Ashwell, Steroid production in the thymus: implications for thymocyte selection. Journal of Experimental Medicine. ,vol. 179, pp. 1835- 1846 ,(1994) , 10.1084/JEM.179.6.1835
Julie H. Marino, Chibing Tan, Ashlee A. Taylor, Caroline Bentley, C. Justin Van De Wiele, Richard Ranne, Marco Paliotta, Thomas A. Broughan, T. Kent Teague, Differential IL-7 responses in developing human thymocytes Human Immunology. ,vol. 71, pp. 329- 333 ,(2010) , 10.1016/J.HUMIMM.2010.01.009
Jeffrey C. Rathmell, Tullia Lindsten, Wei-Xing Zong, Ryan M. Cinalli, Craig B. Thompson, Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis Nature Immunology. ,vol. 3, pp. 932- 939 ,(2002) , 10.1038/NI834
A. R. Khaled, K. Kim, R. Hofmeister, K. Muegge, S. K. Durum, Withdrawal of IL-7 induces Bax translocation from cytosol to mitochondria through a rise in intracellular pH Proceedings of the National Academy of Sciences of the United States of America. ,vol. 96, pp. 14476- 14481 ,(1999) , 10.1073/PNAS.96.25.14476
Ute Koch, Emma Fiorini, Rui Benedito, Valerie Besseyrias, Karin Schuster-Gossler, Michel Pierres, Nancy R. Manley, Antonio Duarte, H. Robson MacDonald, Freddy Radtke, Delta-like 4 is the essential, nonredundant ligand for Notch1 during thymic T cell lineage commitment Journal of Experimental Medicine. ,vol. 205, pp. 2515- 2523 ,(2008) , 10.1084/JEM.20080829
Alison M Michie, Juan Carlos Zúñiga-Pflücker, Regulation of thymocyte differentiation: pre-TCR signals and β-selection Seminars in Immunology. ,vol. 14, pp. 311- 323 ,(2002) , 10.1016/S1044-5323(02)00064-7