Risk factors for developing atopic dermatitis.

摘要: The aim of this thesis was to investigate possible risk factors affecting the development AD. AD is a frequent disease among children and has substantial impact on lives both child its family. A better understanding would enable treatment, prevention information families involved. Previous factor studies have been hampered by an unsuitable study design and/or difficulties in standardization when diagnosing AD, which limit their conclusions. In paper I, we conducted traditional cross-sectional analysis testing 40 for developing at 3 years age. Our data suggested strong heredity confirmed associated with non-functional FLG allele mutations after adjustments confounders. Besides mother's dermatitis father's allergic rhinitis were found increase Perinatal exposure dog only environmental that significantly reduced manifestation, suggesting other, yet unknown increasing prevalence children. Length birth shown be inversely later This led two borderline significant results: duration exclusive breastfeeding alcohol intake during 3rd trimester. Since these could neither rejected nor accepted, decided do in-depth studies, further investigating these, using longitudinal instead approach (paper II & III). II, investigated wheezy symptoms until age 2 depending breastfeeding. We increased but protective effect disorders infancy from adjustment demographics, variants R501X 2282del4 status, parent's pets home (RR 2.09, 95% CI 1.15-3.80, p=0.016). addition, there (p=0.043), as relative proportion not explained fatty acid composition milk, though trend showed higher if milk had low concentrations n-3 acids. III, pregnancy offspring, persisting throughout whole 7 follow-up period (HR 1.44, 1.05-1.99, p=0.024). still confounder education, smoking habits There no association between other atopic endpoints (wheeze episodes, asthma, rhinitis, blood eosinophil count, total IgE, sensitization, cord IgE nasal eosinophilia). However, underlying explanation clear. based collected part ongoing COPSAC cohort. cohort longitudinal, prospective following 411 born mothers asthma. selection high-risk restricts interpretation results they cannot necessarily expanded apply general population.