Overview: Spatial control of signal transduction by caveolae and lipid rafts
作者： Christopher J. Fielding
DOI: 10.1016/S1566-3124(03)12001-9
关键词:
摘要: Abstract Several lines of investigation connect FC homeostasis and signaling via caveolae lipid rafts. Caveolae appear to represent a stabilized, three-dimensional evolution rafts, that can control their content dynamically, both during signal transduction in response loading. In the normal dividing cell, this system limits from cell surface except initiate cycle, retains as required for membrane synthesis, despite presence extracellular lipoprotein acceptors. aging these mechanisms are deranged while caveolin accumulates intracellular vesicles, rather than caveolae, palmitoylation is inhibited. A detailed study relationship between status caveolar function would be great interest. Studies molecular basis effects should also offer many opportunities understand role plasma aging.
sci-hub.se 参考文章(45)
Tong Liu, Monty Krieger, Horng-Yuan Kan, Vassilis I. Zannis, The Effects of Mutations in Helices 4 and 6 of ApoA-I on Scavenger Receptor Class B Type I (SR-BI)-mediated Cholesterol Efflux Suggest That Formation of a Productive Complex between Reconstituted High Density Lipoprotein and SR-BI Is Required for Efficient Lipid Transport Journal of Biological Chemistry. ,vol. 277, pp. 21576- 21584 ,(2002) , 10.1074/JBC.M112103200
Marie-Odile Parat, Paul L. Fox, Palmitoylation of Caveolin-1 in Endothelial Cells Is Post-translational but Irreversible Journal of Biological Chemistry. ,vol. 276, pp. 15776- 15782 ,(2001) , 10.1074/JBC.M006722200
Christopher J. Fielding, Anita Bist, Phoebe E. Fielding, Intracellular cholesterol transport in synchronized human skin fibroblasts. Biochemistry. ,vol. 38, pp. 2506- 2513 ,(1999) , 10.1021/BI981012O
Mark L. LANG, Yih-Wen CHEN, Li SHEN, Hong GAO, Gillian A. LANG, Terri K. WADE, William F. WADE, IgA Fc receptor (FcαR) cross-linking recruits tyrosine kinases, phosphoinositide kinases and serine/threonine kinases to glycolipid rafts Biochemical Journal. ,vol. 364, pp. 517- 525 ,(2002) , 10.1042/BJ20011696
G. Sowa, M. Pypaert, W. C. Sessa, Distinction between signaling mechanisms in lipid rafts vs. caveolae Proceedings of the National Academy of Sciences of the United States of America. ,vol. 98, pp. 14072- 14077 ,(2001) , 10.1073/PNAS.241409998
Erin D. Sheets, Greta M. Lee, Rudolf Simson, Ken Jacobson, Transient confinement of a glycosylphosphatidylinositol-anchored protein in the plasma membrane Biochemistry. ,vol. 36, pp. 12449- 12458 ,(1997) , 10.1021/BI9710939
Annette Uittenbogaard, Yun-shu Ying, Eric J. Smart, Characterization of a cytosolic heat-shock protein-caveolin chaperone complex. INVOLVEMENT IN CHOLESTEROL TRAFFICKING. Journal of Biological Chemistry. ,vol. 273, pp. 6525- 6532 ,(1998) , 10.1074/JBC.273.11.6525
Anita Bist, Christopher J. Fielding, Phoebe E. Fielding, p53 regulates caveolin gene transcription, cell cholesterol, and growth by a novel mechanism. Biochemistry. ,vol. 39, pp. 1966- 1972 ,(2000) , 10.1021/BI991721H
Yi Zhu, Hai-Ling Liao, Nanping Wang, Yuan Yuan, Kuo-Sheng Ma, Lynne Verna, Michael B. Stemerman, Lipoprotein Promotes Caveolin-1 and Ras Translocation to Caveolae Role of Cholesterol in Endothelial Signaling Arteriosclerosis, Thrombosis, and Vascular Biology. ,vol. 20, pp. 2465- 2470 ,(2000) , 10.1161/01.ATV.20.11.2465
Ferruccio Galbiati, Daniela Volonte', Jun Liu, Franco Capozza, Philippe G. Frank, Liang Zhu, Richard G. Pestell, Michael P. Lisanti, Caveolin-1 expression negatively regulates cell cycle progression by inducing G(0)/G(1) arrest via a p53/p21(WAF1/Cip1)-dependent mechanism. Molecular Biology of the Cell. ,vol. 12, pp. 2229- 2244 ,(2001) , 10.1091/MBC.12.8.2229