The amyloid‐β peptide and its role in Alzheimer's disease
作者： Andrew B. Clippingdale , John D. Wade , Colin J. Barrow
DOI: 10.1002/PSC.324
关键词:
摘要: Amyloid formation plays a central role in the cause and progression of Alzheimer's disease. The major component this amyloid is amyloid-β (Aβ) peptide, which currently subject intense study. This review discusses some recent studies area Aβ synthesis, purification structural analysis. Also discussed are proposed mechanisms for Aβ-induced neurotoxicity advances development Aβ-related therapeutic strategies. Copyright © 2001 European Peptide Society John Wiley & Sons, Ltd.
sci-hub.se 参考文章(206)
K. Leonhard, J. M. Herrmann, R. A. Stuart, G. Mannhaupt, W. Neupert, T. Langer, AAA proteases with catalytic sites on opposite membrane surfaces comprise a proteolytic system for the ATP-dependent degradation of inner membrane proteins in mitochondria. The EMBO Journal. ,vol. 15, pp. 4218- 4229 ,(1996) , 10.1002/J.1460-2075.1996.TB00796.X
Rogers J, Bonnell B, Webster S, Charge-based binding of complement component C1q to the Alzheimer amyloid beta-peptide. American Journal of Pathology. ,vol. 150, pp. 1531- 1536 ,(1997)
Tatsuya Inui, Terutoshi Kimura, Yuji Nishiuchi, Hideki Nishio, Synthesis of Amyloid β-Peptides in Solution : Chloroform- Phenol Mixed Solvent Is Essential for Segment Condensation of Sparingly Soluble Protected Peptides Peptide science : proceedings of the ... Japanese Peptide Symposium. ,vol. 1999, pp. 5- 8 ,(2000)
Bruce A. Lamb, Kimberly A. Bardel, Laura S. Kulnane, Jeff J. Anderson, Greg Holtz, Steven L. Wagner, Sangram S. Sisodia, Emily J. Hoeger, Amyloid production and deposition in mutant amyloid precursor protein and presenilin-1 yeast artificial chromosome transgenic mice. Nature Neuroscience. ,vol. 2, pp. 695- 697 ,(1999) , 10.1038/11154
Jean Marx, Neurodegenerative Disease: Searching for Drugs That Combat Alzheimer's Science. ,vol. 273, pp. 50- 50 ,(1996) , 10.1126/SCIENCE.273.5271.50
B Soreghan, J Kosmoski, C Glabe, Surfactant properties of Alzheimer's A beta peptides and the mechanism of amyloid aggregation. Journal of Biological Chemistry. ,vol. 269, pp. 28551- 28554 ,(1994) , 10.1016/S0021-9258(19)61939-3
B. D. Shivers, C. Hilbich, G. Multhaup, M. Salbaum, K. Beyreuther, P. H. Seeburg, Alzheimer's disease amyloidogenic glycoprotein: expression pattern in rat brain suggests a role in cell contact. The EMBO Journal. ,vol. 7, pp. 1365- 1370 ,(1988) , 10.1002/J.1460-2075.1988.TB02952.X
Colin J. Barrow, Akikazu Yasuda, Peter T.M. Kenny, Michael G. Zagorski, Solution conformations and aggregational properties of synthetic amyloid beta-peptides of Alzheimer's disease. Analysis of circular dichroism spectra. Journal of Molecular Biology. ,vol. 225, pp. 1075- 1093 ,(1992) , 10.1016/0022-2836(92)90106-T
T. Iwatsubo, Takaomi C Saido, DM Mann, VM Lee, John Q Trojanowski, Full-length amyloid-beta (1-42(43)) and amino-terminally modified and truncated amyloid-beta 42(43) deposit in diffuse plaques. American Journal of Pathology. ,vol. 149, pp. 1823- 1830 ,(1996)
David H. Small, Catriona A. McLean, Alzheimer's disease and the amyloid beta protein: What is the role of amyloid? Journal of Neurochemistry. ,vol. 73, pp. 443- 449 ,(2002) , 10.1046/J.1471-4159.1999.0730443.X