Simple mathematical model of pathologic microsatellite expansions: when self-reparation does not work.
作者： Boris Veytsman , Leila Akhmadeyeva
DOI: 10.1016/J.JTBI.2006.03.008
关键词:
摘要: We propose a simple model of pathologic microsatellite expansion, and describe an inherent self-repairing mechanism working against expansion. prove that if the probabilities elementary expansions contractions are equal, always self-repairing. If these different, self-reparation does not work. Mosaicism, anticipation reverse mutation cases discussed in framework model. explain phenomena provide some theoretical evidence for their properties, example, rarity mutations.
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