Pagetoid dyskeratosis of the nipple epidermis: an incidental finding mimicking Paget's disease of the nipple

摘要: Pagetoid dyskeratosis (PD) is considered a selective keratinocytic response in which small part of the normal population pale keratinocytes induced to proliferate. PD has been found incidentally squamous epithelium skin and mucosas various locations, but not nipple. In cases cells are conspicuous, there danger overdiagnosis. retrospective study, we describe location incidence other nipple epidermis, 288 mastectomy specimens from women operated on for breast carcinoma, situ or infiltrating, selected consecutively our histopathologic files. addition conventional histologic methods an immunohistochemical study was performed cases. 184 (63.9%) prominent finding 37 (12.8%) Toker (TCs) were identified by standard light microscopy 24 (8.3%) nipples. Paget carcinoma (PCCs) 12 (4.2%) cases, 9 (3.1%) they incidental finding. The profile each type as follows: cells, EMA-,LMWCK-,CK7-,HMWCK+, CEA-, HER2/neu protein-, HMB45-, HPV-; TCs, EMA+, LMWCK+, CK7+, HMWCK-, PCCs, CEA+, protein+, HPV-. conclusion, friction may be stimulus appearance cells. must distinguished clear Bowen's disease, pagetoid melanoma cell papulosis, koilocytes, artifactual glycogen-rich A combination markers useful this distinction; however, routine usually adequate recognizing PD. Pathologists should familiar with features epidermis avoid misdiagnosis.