Unusual Nucleophilic Addition of Grignard Reagents in the Synthesis of 4-Amino-pyrimidines.

摘要: Pyrimidines have always received considerable attention because of their importance in synthesis and elucidation biochemical roles, in particular that vitamin B1. Herein, we describe a reaction pathway Grignard reagent-based synthesis substituted pyrimidines. A general α-keto-2-methyl-4-amino pyrimidines C6-substituted analogues from 4-amino-5-cyano-2-methylpyrimidine is reported. The presence the nitrile substituent starting material also results an unusual leading to 1,2-dihydropyrimidines. reagents give normal pyrimidine products under standard conditions can be switched dihydropyrimidines by holding at 0 °C before quenching.