Vinylic telluride derivatives as promising pharmacological compounds with low toxicity.

摘要: The aim of the present study was to evaluate pharmacological and toxicological properties (Z)-2-(methylthio)-1-(butyltelluro)-1-phenylethene 1a, (Z)-1-(4-methylphenylsulfonyl)-2-(phenyltelluro)-2-phenylethene 1b, (Z)-2-(butyltelluro)-1-(benzylthio)-1-heptene 1c (Z)-2-(phenylthio)-1-(butyltelluro)-1-phenylethene 1d. In vitro, vinylic telluride derivatives 1d were more effective in reducing lipid peroxidation than compound 1b. maximal inhibitory effect on following order: 1a = > Compound 1b potent inhibiting δ-ALA-D activity (δ-aminolevulinate dehydratase) compounds Based vitro presented by (an antioxidant) (a pro-oxidant), parameters assessed vivo ex rats. Calculated LD50 administered oral route, 20.5 1.44 µmol kg−1, respectively. induced behavioral alterations open field test. Renal spleenic activities inhibited rats treated orally with 1a. stimulated liver spleen Rats had increased hepatic, renal peroxidation. hepatic markers not altered when at doses around LD50, while high changed aspartate aminotransferase urea levels. results, this demonstrated that are promising antioxidant compounds. Ex data reinforce as a drug for detailed studies. Copyright © 2008 John Wiley & Sons, Ltd.