Doxycycline administration improves fascial interface in hernia repair.

摘要: Abstract Background Despite improvements in ventral hernia repair techniques, their recurrence rates are unacceptably high. Increased levels of matrix metalloproteinases (MMPs) and reduced collagen-1 to -3 ratios implicated incisional formation. We have recently shown doxycycline treatment for 4 wk after MMP levels, significantly increased ratios, tensile strength repaired interface fascia. However, this increase was not statistically significant. In study, we extended duration determine whether would impact the Materials methods Thirty-two male Sprague–Dawley rats underwent incision creation subsequent with polypropylene mesh. The animals received either saline (n = 16) or beginning from 1 day before until end survival time 6 wk 12 wk (n = 16). Tissue samples were investigated MMPs collagen subtypes using Western blot procedures, tensiometric analysis performed. Results At both 6 repair, doxycycline-treated mesh fascia (MFI) tissue showed a significant when compared untreated control MFI. groups, collagen-1, -2, remarkably 6 wk, MFI group decrease MMP-2, an MMP-3, no change MMP-9. 12 wk, MMP-9 remarkable reduction, whereas MMP-2 protein group. Conclusions Doxycycline administration results improved fascial along ratios.