New drug design with covalent modifiers

摘要: Introduction: A major challenge for drug design is the alarming increase in resistance, mutations and toxicity. In recent years, covalent drugs have become a promising option to address these problems, due their significant advantages. These advantages include ability target rare, non-conserved residues, shallow binding sites of proteins retain with receptor very long time.Areas covered: This review shows increasing progress rational virtual screening future accurately predicting effective through silico screening.Expert opinion: All current clinically approved were discovered by chance instead systematic design. There commendable effort towards high-throughput accurate discovery new inhibitors, which may problems resistance mutation. However, despite progressi...