AVALIAÇÃO DA ATIVIDADE MUTAGÊNICA DA TALIDOMIDA PELO

作者： Lídia M. Lima , Chung M. Chin , Júlio de Mesquita Filho , Eliana A. Varanda , Jean L. Santos

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摘要: PALAVRAS-CHAVE : talidomida; Salmonella typhimurium ; testes de mutagenicidade. ABSTRACT The reintroduce of thalidomide, known as theratogenic drug, potentially useful in several diseases like AIDS, cancer , tuberculosis arthritis, Crohn disease, mieloma and mielodisplasic syndromes requires genotoxic evaluation for human use. In this work we evaluated the capacity thalidomide induce mutation using AMES test with TA100 TA102 strains on presence or absence metabolic activation. results showed that not presents mutagenic potency, although, another tests must be realized purpose testify observation.

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AVALIAÇÃO DA ATIVIDADE MUTAGÊNICA DA TALIDOMIDA PELO

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AVALIAÇÃO DA ATIVIDADE MUTAGÊNICA DA TALIDOMIDA PELO

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