Thalidomide and metabolites: indications of the absence of 'genotoxic' carcinogenic potentials.

摘要: Abstract Because of the reintroduction into human therapeutics thalidomide, a recognized developmental toxicant in humans, there has been concern about its potential for inducing other health effects as well. The present study is concerned with possible mutagenicity and carcinogenicity this chemical. Using expert system, META, series putative metabolites thalidomide was generated. In addition to known or hypothesized (N=12), number additional (N=131) were identified by META. structures these chemicals subjected structure–activity analyses using predictive CASE/MULTICASE models toxicity, rodent Salmonella. While some predicted be toxicants, none them carcinogens. Putative containing hydroxamic acid hydroxylamine moieties mutagens. None `known' contained reactive moieties. Whether such intermediates are indeed generated whether they either unstable presence oxygen react rapidly nucleophiles unknown.