Mouse Models of Osteoarthritis: Surgical Model of Posttraumatic Osteoarthritis Induced by Destabilization of the Medial Meniscus
作者： Kirsty L. Culley , Cecilia L. Dragomir , Jun Chang , Elisabeth B. Wondimu , Jonathan Coico
DOI: 10.1007/978-1-4939-1619-1_12
关键词:
摘要: The surgical model of destabilization the medial meniscus (DMM) has become a gold standard for studying onset and progression posttraumatic osteoarthritis (OA). DMM mimics clinical meniscal injury, known predisposing factor development human OA, permits study structural biological changes over course disease. In addition, when applied to genetically modified or engineered mouse models, this procedure dissection relative contribution given gene OA initiation and/or progression. This chapter describes requirements induction in provides guidelines tools subsequent histological, immunohistochemical, molecular analyses. Methods assessment contributions selected genes strains are also provided.
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