Cartilage and bone changes during development of post-traumatic osteoarthritis in selected LGXSM recombinant inbred mice.

摘要: Summary Introduction Little evidence is available on the natural course of osteoarthritis (OA) development and genes that protect predispose individuals to it. This study was designed compare strain-dependent OA its association with tissue regeneration in mice. Two recombinant inbred lines LGXSM-6 LGXSM-33 generated from LG/J SM/J intercross were used. Previous studies indicated can regenerate both articular cartilage ear hole punch while cannot. Methods Transection medial meniscotibial ligament performed 10-week-old male mice induce OA. Cartilage damage analyzed by histology bone morphology evaluated using micro-computed tomography (CT). Ear punches measurement residual diameter. Results analysis showed developed a significantly higher grade than LGXSM-6. Bone had substantial subchondral trabecular thickening 8 weeks post-surgery, loss over time. We also confirmed heal tissues better LGXSM-33. Conclusions found be negatively correlated degree regeneration. LGXSM-33, poor healer (and cartilage), more compared LGXSM-6, which regenerative ability for cartilage. The phenotypic differences observed here are due genetic further suggesting similar sets physiological processes gene variants may mediate variation