Chemometric and Transcriptomic Profiling, Microtubule Disruption and Cell Death Induction by Secalonic Acid in Tumor Cells.

摘要: Nature is an indispensable source of new drugs, providing unique bioactive lead structures for drug discovery. In the present study, secalonic acid F (SAF), a naturally occurring ergochrome pigment, was studied its cytotoxicity against various leukemia and multiple myeloma cells by resazurin assay. SAF exhibited cytotoxic activity on both cells. Generally, were more sensitive to than NCI-H929 most affected among tested panel cell lines taken further studies assess mode action those Cell cycle analysis revealed that induced S G2/M arrest in SAF-associated apoptosis necrosis resulted cytotoxicity. inclined disassembly tubulin network, which may also account COMPARE hierarchical cluster analyses transcriptome-wide expression profiles NCI tumor line identified genes involved numerous cellular processes (e.g., differentiation, migration, other signaling pathways) notably correlated with log10IC50 values acid. conclusion, study supports therapeutic potential treat myeloma.