The CCND1 c.870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma.
作者： Niels Weinhold , David C Johnson , Daniel Chubb , Bowang Chen , Asta Försti
DOI: 10.1038/NG.2583
关键词:
摘要: A number of specific chromosomal abnormalities define the subgroups multiple myeloma. In a meta-analysis two genome-wide association studies myeloma including total 1,661 affected individuals, we investigated risk for developing tumor karyotype. The t(11;14)(q13;q32) translocation in which CCND1 is placed under control immunoglobulin heavy chain enhancer was strongly associated with c.870G>A polymorphism (P = 7.96 x 10(-11)). These results provide model constitutive genetic factor translocation.
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