Synergy of two human endogenous retroviruses in multiple myeloma
作者： Kathrine LM Schmidt , Annette J Vangsted , Bettina Hansen , Ulla B Vogel , N Emil U Hermansen
DOI: 10.1016/J.LEUKRES.2015.06.014
关键词: Genetics 、 Endogeny 、 X chromosome 、 Multiple myeloma 、 SNP array 、 Chromosome 、 Endogenous retrovirus 、 Biology 、 Genotype 、 Genetic epidemiology
摘要: Multiple myeloma (MM) is a severe, incurable neoplasm of the plasma cells. In this study we have used genetic epidemiology to associate risk MM with endogenous retroviral loci in humans. We SNP analysis on Sequenom platform and statistical SPSS. Markers near two loci, HERV-Fc1 chromosome X HERV-K 1, were associated MM. Moreover, there was strong gene-gene interaction relation take as indirect confirmation association.
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