Chapter 38 – Guillain-Barre Syndrome

摘要: Publisher Summary Guillain-Barre syndrome (GBS) has emerged as the most frequent cause of acute flaccid paralysis worldwide. Its form, inflammatory demyelinating polyneuropathy (AIDP), is prototypic acquired disease peripheral nervous system. The importance GBS in this text lies both its own prominence a major neurologic morbidity and similarities contrasts with disorders central This chapter outlines history GBS, followed by clinical manifestations, pathology AIDP, pathophysiology, molecular genetics. It noted that multiple sclerosis (MS) represent immune-mediated PNS CNS, respectively. data for suggests immunologic mechanism can involve mimicry, at least some variants. Finally, MS, it likely mechanisms render axon vulnerable. These include damage bystander to disease, consequence intimate cell-cell interactions between myelin-forming cell axon, possibly target immune attack.