CD44 Expression and Tumour Cell Density Correlate with Response to Tamoxifen/Carboplatin Chemotherapy in Glioblastomas

摘要: In order to identify response predictors for a post-operative glioblastoma therapy consisting of tamoxifen, carboplatin and radiotherapy, expression 12 antigens was evaluated in 36 newly diagnosed tumours 13 recurrences. Results were correlated with the clinical course disease. Antigen assessed immunohistochemically CD44s, TGF-beta2, TGF-alpha, progesterone receptor, estrogen EGFR, urokinase, urokinase inhibitor 1, CD87, p53 protein Ki-67. Vessel density determined by labelling endothelia von Willebrand factor. Response chemotherapy positively cell (p < 0.05) negatively CD44 over-expression 0.02). Further, positive correlation between age negative accumulation 0.01) found. tumour recurrences significantly higher local than distant multifocal 0.02), suggesting that may predominantly be associated adhesion glioblastomas.