CD44 is a metastasis suppressor gene for prostatic cancer located on human chromosome 11p13.

摘要: Abstract We have used microcell fusion-mediated chromosomal transfer to introduce normal human chromosomes into highly metastatic rodent prostatic cancer cells map the location of a metastasis suppressor gene(s). Using this approach, several regions been identified that harbor such genes, including chromosome 11 between p11.2–13 (T. Ichikawa et al., Cancer Res., 52: 3486–3490, 1992, 54: 2299–2302, 1994; N. Nihei Genes Chromosomes & Cancer, 14: 112–119, 1995; C. W. Rinker-Schaeffer 6249–6256, 1994). positional cloning, gene, termed KAI1, was identified, which is located at 11p11.2 (5). Overexpression KAI1 results in suppression certain Dunning R-3327 rat sublines, as AT6.1, without other A%3.1. This suggests an additional gene within 11p11.2–13 region. The CD44 on 11p13 and encodes integral membrane glycoprotein participates specific cell-cell cell-extracellular matrix interactions. Down-regulation expression both mRNA protein levels correlates with potential system sublines. Transfection-induced enhanced Mr 85,000 standard form AT3.1 greatly suppresses their ability lungs vivo growth rate or tumorigenicity. These suggest for decreased involved progression state.