Preliminary evaluation of circulating microRNAs as potential biomarkers in paracoccidioidomycosis.
作者： Junya De Lacorte Singulani , Julhiany De Fátima Da Silva , Fernanda Patricia Gullo , Marina Célia Costa , Ana Marisa Fusco-Almeida
DOI: 10.3892/BR.2017.849
关键词:
摘要: MicroRNAs (miRNAs) are small RNAs (length, 19-24 nucleotides) that regulate gene expression by either mRNA degradation or translational inhibition of proteins. Circulating miRNAs, which extremely stable and protected from RNAse-mediated in body fluids, have appeared as candidate biomarkers for numerous diseases. However, little is known about circulating miRNAs fungal infections. Paracoccidioidomycosis (PCM) caused the Paracoccidioides species, endemic Central South America, with predominance adult male workers rural areas. The current study aimed to identify a serum miRNA profile could serve novel diagnostic biomarker PCM. Total RNA was isolated levels were compared between patients PCM healthy control subjects using reverse transcription-quantitative polymerase chain reaction. Bioinformatic analysis used evaluate potential roles these Eight differentially expressed samples These associated apoptosis immune response. identified facilitate understanding regulatory mechanisms involved host-parasite interaction Furthermore, considering diagnosis presents difficulties, may this disease.
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