Effects of Ursodeoxycholic Acid on Hemodynamic and Renal Function Abnormalities Induced by Obstructive Jaundice in Rats
作者： Jorge L. Poo , Alma Estanes , José Pedraza-Chaverrí , Cristino Cruz , Misael Uribe
DOI: 10.3109/08860229509036370
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摘要: The mechanism of renal function abnormalities in experimental biliary cirrhosis can be partially explained by the absence gastrointestinal bile flow, which predisposes to translocation intestinal endotoxin, a potent vasoconstrictor. Since acids prevent absorption endotoxins, we aimed evaluate effects ursodeoxycholic acid (UDCA) administration on and hemodynamic induced 1 week obstructive jaundice rats. Methods: Fifty-two rats were used; 30 had ligation common duct, 22 sham operated. Bile duct ligated randomly blindly assigned receive UDCA (25 mg/kg/day, n = 14) or placebo (n 16) during week. Sham received no treatment. Portal pressure (PP) as well creatinine clearance (CrCl), urinary sodium (US), plasma renin activity (PRA) evaluated. Results are mean ± SEM, with significant value p < 0.05. Results: (10.4 1.1 vs. 12.1 0.8 mm Hg) was significantl...
sci-hub.se 参考文章(37)
Tapia E, Chávez Mt, Pedraza-Chaverrí J, Calleja C, del Carmen Uribe M, Romero L, Peña Jc, Cruz C, Ibarra-Rubio Me, Pathophysiology of experimental nephrotic syndrome induced by puromycin aminonucleoside in rats. I. The role of proteinuria, hypoproteinemia, and renin-angiotensin-aldosterone system on sodium retention. Revista De Investigacion Clinica. ,vol. 42, pp. 29- 38 ,(1990)
John B.K. Allotey, Mortimer Levy, Temporal relationships between urinary salt retention and altered systemic hemodynamics in dogs with experimental cirrhosis. Journal of Laboratory and Clinical Medicine. ,vol. 92, pp. 560- 569 ,(1978) , 10.5555/URI:PII:0022214378901075
Cahill Cj, Bailey Me, Pain Ja, Bile salts, endotoxin and renal function in obstructive jaundice. Surgery gynecology & obstetrics. ,vol. 165, pp. 519- 522 ,(1987)
Arieh Bomzon, Ofer Binh, Laurence M. Blendis, Hypotension in experimental cirrhosis Journal of Hepatology. ,vol. 17, pp. 116- 123 ,(1993) , 10.1016/S0168-8278(05)80531-8
J. Kountouras, P. J. Scheuer, B. H. Billing, Prolonged bile duct obstruction: a new experimental model for cirrhosis in the rat. British journal of experimental pathology. ,vol. 65, pp. 305- 311 ,(1984)
Jorge L. Poo, Gerard Feldmann, Serge Erlinger, Alain Braillon, Christophe Gaudin, Micheline Dumont, Didier Lebrec, Ursodeoxycholic acid limits liver histologic alterations and portal hypertension induced by bile duct ligation in the rat Gastroenterology. ,vol. 102, pp. 1752- 1759 ,(1992) , 10.1016/0016-5085(92)91739-Q
F Mashige, N Tanaka, A Maki, S Kamei, M Yamanaka, Direct spectrophotometry of total bile acids in serum. Clinical Chemistry. ,vol. 27, pp. 1352- 1356 ,(1981) , 10.1093/CLINCHEM/27.8.1352
A. Ward, R.N. Brogden, R.C. Heel, T.M. Speight, G.S. Avery, Ursodeoxycholic acid: a review of its pharmacological properties and therapeutic efficacy Drugs. ,vol. 27, pp. 95- 131 ,(1984) , 10.2165/00003495-198427020-00001
H. J. R. Evans, V. Torrealba, C. Hudd, M. Knight, The effect of preoperative bile salt administration on postoperative renal function in patients with obstructive jaundice British Journal of Surgery. ,vol. 69, pp. 706- 708 ,(2005) , 10.1002/BJS.1800691207
Carol E.H. Scott-Conner, James B. Grogan, Kenneth S. Scher, Jack M. Bernstein, Constance Bailey-Berk, Impaired bacterial killing in early obstructive jaundice. American Journal of Surgery. ,vol. 166, pp. 308- 310 ,(1993) , 10.1016/S0002-9610(05)80981-X