Chemokines and chemokine receptors : Their role in allergic airway disease

摘要: One of the hallmarks allergic pulmonary disorders is accumulation an abnormally large number leukocytes including eosinophils, neutrophils, lymphocytes, basophils, and macrophages in lung (1). There now substantial evidence that under control T are major effector cells pathogenesis asthma. Therefore, understanding mechanisms by which eosinophils accumulate activated tissues a fundamental question very relevant to diseases. Another characteristic inflammation activation resulting release biologically active mediators, such as histamine from mast basophils. It apparent chemokines potent leukocyte chemoattractants, cellular activating factors, releasing regulators homeostatic immunity, making them particularly important airway asthma (2). In this regard, attractive new therapeutic targets for treatment disease. This article focuses on recently emerging data importance their receptors inflammation.